Luis M. Montuenga

RNA and protein are not interchangeable in single-cell spatial multi-omics

This study shows that spatial RNA and protein measurements are largely overlapping for lineage markers and abundance but discordant for specific molecules and spatial features, indicating they are complementary rather than interchangeable.

MDM2 stabilization of Notch intracellular domain upon DNA damage plays a major role in non-small cell lung carcinoma response to platinum chemotherapy

This study identifies MDM2 stabilization of NICD in response to platinum chemotherapy in NSCLC, showing that targeting MDM2 and NICD improves survival and reduces tumor growth.

FMO4 drives lung adenocarcinoma by stabilizing the MAT2A/MAT2B complex and hindering ferroptosis

This study identifies FMO4 as a driver of lung adenocarcinoma by stabilizing the MAT2A/MAT2B complex and inhibiting ferroptosis.

Comparison of RNA-seq and Microarray Platforms for Splice Event Detection using a Cross-Platform Algorithm

This study compares RNA-seq and junction arrays for detecting splice events using a cross-platform algorithm, finding RNA-seq superior for novel events but both coherent for known regions.