Paracrine and autocrine R-spondin signalling is essential for the maintenance and differentiation of renal stem cells
Valérie Vidal, Elodie P. Gregoire, Emmanuelle Szenker‐Ravi, Marc Leushacke, Bruno Reversade, Marie‐Christine Chaboissier, Andreas Schedl
This study shows that RSPO1 and RSPO3 are essential for WNT/β-catenin signaling in kidney development, with their deletion causing loss of renal progenitors and failure of MET.
bioRxiv · Nov 29, 2019 · PreprintDevelopmental Biology