Marie‐Christine Chaboissier

This study shows RSPO1/WNT/B-catenin signaling suppresses androgen signaling during ovarian development in mice, with androgen receptor inhibition rescuing development in mutants.

This study shows that ovarian cellular diversity arises from spatially organized, transcriptionally heterogeneous coelomic epithelium progenitors in fetal mouse and human ovaries, which are primed toward supporting or steroidogenic identities.

This study shows NR2F2 is essential for fetal Leydig cell development in mouse testes and links it to 46, XY DSD associated with NR2F2 variants.

The paper identifies and characterizes a previously uncharacterized supporting-like cell lineage in developing mouse gonads, showing its origin, specification, and sex-specific differentiation.

The paper uses single-cell RNA sequencing to study gene expression dynamics in mouse germ cells during sex determination, identifying sex-specific regulatory patterns and meiotic gene regulation.

The paper shows that Sox8 and Sox9 redundantly compensate for Rspo1 loss in female-to-male sex reversal in mice, preventing ovarian-to-testicular reprogramming.

This study shows that RSPO1 and RSPO3 are essential for WNT/β-catenin signaling in kidney development, with their deletion causing loss of renal progenitors and failure of MET.

The paper uses single-cell RNA sequencing to study sex determination in mouse gonadal somatic cells, identifying early progenitors and sex-specific fate acquisition in different cell lineages.