A chimeric human-mouse lung vascular model using induced pluripotent stem cells reveals insights into the pathogenesis of BMPR2-related pulmonary hypertension
Alexander M. Holtz, Marcus Vorpahl, Mohamed J. Ahmed, Eric D. Austin, Pushpinder Bawa, Carlos Villacorta-Martín, Mervin C. Yöder, Darrell N. Kotton
The paper develops a chimeric human-mouse lung vascular model using hiPSCs to study BMPR2-related pulmonary hypertension, revealing novel molecular and functional defects in human endothelial cells.
bioRxiv · May 2, 2026 · PreprintGenetics