Pushpinder Bawa

Immunomodulatory RIG-I Agonist SLR14 Confers Protection Against a Range of Highly Pathogenic Negative Sense RNA viruses

SLR14, an immunomodulatory RIG-I agonist, provides broad-spectrum antiviral protection against multiple highly pathogenic negative-sense RNA viruses in vitro and in vivo.

Generation of effector CD4+ T cells from Human iPSC

This paper generates functional CD4+ T cells from human iPSC by modulating Notch signaling, showing cytokine diversity and transcriptional similarity to blood CD4+ T cells.

A non-enzymatic role for METTL3 as an Androgen Receptor co-regulator that promotes prostate cancer proliferation.

This study identifies METTL3 as a non-enzymatic AR co-regulator that promotes prostate cancer proliferation by supporting AR-driven transcriptional programs.

Mesothelial Plasticity Specifies a Pleural Immune Circuit that Orchestrates Lung Regeneration

The paper identifies mesothelial cell plasticity as a key determinant of regenerative versus degenerative lung repair by comparing pneumonectomy and chronic lung allograft dysfunction models.

A chimeric human-mouse lung vascular model using induced pluripotent stem cells reveals insights into the pathogenesis of BMPR2-related pulmonary hypertension

The paper develops a chimeric human-mouse lung vascular model using hiPSCs to study BMPR2-related pulmonary hypertension, revealing novel molecular and functional defects in human endothelial cells.

AT2-intrinsic Z-AAT expression drives conserved inflammatory and proteotoxic stress responses and predisposes to emphysema

This study shows that Z-AAT expression in AT2 cells causes stress responses and increases emphysema risk in AATD.

The chromatin remodeling complex PRC2 safeguards cell fate in alveolar epithelial type 2 cells

This study shows that PRC2 maintains AT2 cell fate in the adult lung by preventing transitions to ABI and basal-like states, both in vitro and in vivo.

Lentiviral-mediated gene complementation rescues pathogenic ABCA3 variants

This study tests lentiviral-mediated ABCA3 gene complementation in cell lines with specific pathogenic variants, showing partial rescue of cellular functions and differential effects based on variant type.

Bidirectional fibrogenic cross-talk revealed in a human iPSC-derived epithelial-mesenchymal co-culture model of pulmonary fibrosis

The paper establishes a human iPSC-derived co-culture model of pulmonary fibrosis that reveals bidirectional fibrogenic epithelial-mesenchymal crosstalk and identifies potential druggable pathways.

A stem cell-based platform for functional analysis of genetic variants in lung disease

This study develops an iPSC-based platform to functionally analyze genetic variants in lung disease, demonstrating its application in diagnosing a variant of uncertain significance in primary ciliary dyskinesia.

SOX2 utilizes FOXA1 as a heteromeric transcriptional partner to drive proliferation in therapy-resistant prostate cancer

This study identifies SOX2 and FOXA1 as a transcriptional partnership driving proliferation and lineage plasticity in therapy-resistant prostate cancer.

Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition

The paper identifies early molecular and functional signatures in cardiac AL amyloidosis patients with abnormal GLS and reduced inflammatory markers despite no significant amyloid fibril deposition.

Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme

This study generates lung-specific mesenchyme from mouse iPSCs, identifies key signaling pathways, and demonstrates functional interactions with lung epithelial progenitors.