Carlos Villacorta-Martín

The paper develops a chimeric human-mouse lung vascular model using hiPSCs to study BMPR2-related pulmonary hypertension, revealing novel molecular and functional defects in human endothelial cells.

This study shows that Z-AAT expression in AT2 cells causes stress responses and increases emphysema risk in AATD.

This study shows that PRC2 maintains AT2 cell fate in the adult lung by preventing transitions to ABI and basal-like states, both in vitro and in vivo.

This study generates lung-specific mesenchyme from mouse iPSCs, identifies key signaling pathways, and demonstrates functional interactions with lung epithelial progenitors.

The paper shows that fetal lung contains hemogenic endothelial cells capable of undergoing endothelial to hematopoietic transition to generate de-novo hematopoietic stem and progenitor cells.

This paper reports the derivation of airway basal stem cells from human iPSCs, demonstrating their ability to self-renew and differentiate into airway epithelial cell types, and model lung diseases.

This study uses human stem cell-derived alveolar type 2 cells to model SARS-CoV-2 infection, revealing rapid inflammatory responses and drug efficacy against the virus.

Human iPSC-derived alveolar type II-like and airway epithelial cells adapted to two-dimensional air-liquid interface culture express ACE2 and TMPRSS2 at frequencies comparable to primary lung epithelial controls.

The paper maps cell fate trajectories of human PSC-derived distal lung progenitors using scRNA-seq and identifies developmental plasticity regulated by Wnt signaling.