Targeted regulation of plasmid DNA expression in eukaryotic cells with a methylated-DNA-binding activator
Isioma Enwerem-Lackland, Eric Warga, Margaret Dugoni, Jacob J. Elmer, Karmella Ann Haynes
The paper introduces a system to regulate plasmid DNA expression in eukaryotic cells by targeting methylated DNA using a fusion protein that binds to GATC motifs.
bioRxiv · Nov 1, 2021 · PreprintSynthetic Biology