Nascent transcript analysis of glucocorticoid crosstalk with TNF defines primary and cooperative inflammatory repression
Sarah K. Sasse, Margaret Gruca, Mary Ann Allen, Vineela Kadiyala, Tengyao Song, Fabienne Gally, Arnav A. Gupta, Miles A. Pufall, Robin D. Dowell, Anthony N. Gerber
The paper uses GRO-seq to show glucocorticoids rapidly repress transcription without local GR occupancy and induce anti-inflammatory effects through GR-NF-kB cooperation.
bioRxiv · Jan 18, 2019Molecular Biology