Author
Duke University
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Wei Zhu, Michael Tian, Yuncheng Duan…·Raluca Gordân
This study quantifies intrinsic dCas9-DNA recognition using TANGO, identifying key factors affecting gRNA performance and revealing new aspects of dCas9 specificity.
Richard W. Doty, Maria A. ter Weele, Alejandro Barrera…·Andrew S. Allen
FRACTEL improves power and replication in CRISPR screens by analyzing region-level effects and informing experimental design.
Lexi R. Bounds, Alejandro Barrera, Maria A. ter Weele…·Charles A. Gersbach
This study identifies hundreds of new cis-regulatory element-gene connections in the MHC locus using CRISPR screens and single-cell transcriptomics, revealing cell type-specific regulatory mechanisms.
Wancen Mu, Tianyou Luo, Alejandro Barrera…·Yun Li
This paper introduces launch-dCas9, a machine learning framework to predict guide RNA effects in CRISPR epigenome editing, showing high accuracy and improved gRNA selection.