Author

Richard W. Doty

Duke UniversityORCID 0000-0003-4197-4920Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 2 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 3 Research Focus:benchmarking· 2 Assay:CRISPR screen· 2 Research Focus:differential expression· 1 Assay:imaging· 1 Research Focus:perturbation response prediction· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Alejandro BarreraiD· 2 shared Andrew S. AlleniD· 2 shared Charles A. GersbachiD· 2 shared Lexi R. BoundsiD· 2 shared Alexander C. Nelson· 1 shared Bruce A. CorlissiD· 1 shared Corbin Mathews· 1 shared Gregory E. CrawfordiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioinformatics

Alejandro BarreraORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJul 7, 2026

Region-Level Design and Analysis of CRISPR Perturbation Screens with FRACTEL

Richard W. Doty, Maria A. ter Weele, Alejandro Barrera…·Andrew S. Allen

FRACTEL improves power and replication in CRISPR screens by analyzing region-level effects and informing experimental design.

DOI 10.64898/2026.07.06.736794

CRISPR screenstatistical model

𝕏 PostBluesky

GenomicsCell GenomicsPeer-reviewedFeb 1, 2025

Characterization and bioinformatic filtering of ambient gRNAs in single-cell CRISPR screens using CLEANSER

Siyan Liu, Marisa C. Hamilton, Thomas Cowart…·Charles A. Gersbach

The paper develops CLEANSER, a model to filter ambient gRNAs in single-cell CRISPR screens, improving gRNA-cell assignment accuracy and differential gene expression analysis.

9 citations

CRISPR screenstatistical model

𝕏 PostBluesky

BioinformaticsMicrocirculationPeer-reviewedMar 16, 2020

REAVER: Improved Analysis of High-resolution Vascular Network Images Revealed Through Round-robin Rankings of Accuracy and Precision

Bruce A. Corliss, Richard W. Doty, Corbin Mathews…·Shayn M. Peirce

REAVER is a tool for analyzing vascular network images, outperforming existing software in accuracy and precision across multiple metrics.

75 citations

imagingstatistical model

𝕏 PostBluesky