BiochemistryJournal of Medicinal ChemistryPeer-reviewed
An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
Pelin Kaya, Elisabeth Schaffner‐Reckinger, Ganesh babu Manoharan…·Daniel Abankwa
The paper develops a novel PDE6D inhibitor, Deltaflexin3, which synergizes with Sildenafil to inhibit KRAS mutant cancer cell growth, though survival data suggest further exploration of K-Ras and PDE6D interplay.
24 citations