Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages
Mingwei Min, Tycho Mevissen, Maria De Luca, David Komander, Catherine Lindon
This study shows that K11 ubiquitin linkages, not K48, are critical for efficient APC/C-mediated substrate degradation during mitotic exit, with Cdh1 specifying this linkage preference.
bioRxiv · Mar 6, 2015Cell Biology