Author

David Komander

Primary ORCID profile (0000-0002-8092-4320 · 8 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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David KomanderiD8 papers · The University of Melbourne

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Catherine Lindon· 1 shared Cynthia WolbergeriD· 1 shared Katerina Growkova· 1 shared Marcello Clerici· 1 shared Maria De Luca· 1 shared Marie Morrow· 1 shared Michael Morgan· 1 shared Michal Simicek· 1 shared

Activity by Year

2015-2017 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCell Biology

Catherine Lindon

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2 papers

Recent·Most cited

Active site alanine substitutions can convert deubiquitinating enzymes into avid ubiquitin-binding domains

Marie Morrow, Michael Morgan, Marcello Clerici, Katerina Growkova, Ming Yan, David Komander, Michal Simicek, Titia Sixma, Cynthia Wolberger

The paper shows that replacing the catalytic cysteine in DUBs with alanine increases their ubiquitin binding affinity, potentially causing unintended physiological effects.

bioRxiv · Dec 22, 2017 · PreprintBiochemistry

Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages

Mingwei Min, Tycho Mevissen, Maria De Luca, David Komander, Catherine Lindon

This study shows that K11 ubiquitin linkages, not K48, are critical for efficient APC/C-mediated substrate degradation during mitotic exit, with Cdh1 specifying this linkage preference.

bioRxiv · Mar 6, 2015Cell Biology