In vivo validation of novel non-invasive PHP.eB AAVs as a potential therapeutic approach for alpha-Synucleinopathies
Maria Fouka, Iraklis Tsakogias, Elena Georgia Gialinaki, Athanasios Stavropoulos, Christiane Volbracht, Louis De Muynck, Diederik Moechars, Ronald Melki, George K. Tofaris, Leonidas Stefanis, Maria Xilouri
This study evaluates PHP.eB AAVs for reducing alpha-synuclein burden in a mouse model of alpha-synucleinopathies, showing reduced pathology and motor deficits.
Acta Neuropathologica Communications · Sep 29, 2025Peer-reviewedNeuroscience