Author

Diederik Moechars

Johnson & Johnson (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Louis De MuynckiD· 3 shared Arjan Buist· 2 shared Gajanan J. SatheiD· 2 shared Géraldine GeldersiD· 2 shared Gopal P. SapkotaiD· 2 shared Sascha RöthiD· 2 shared Thomas MacartneyiD· 2 shared Abigail Brewer· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersNeuroscience

Louis De MuynckORCID

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Author profile →

3 papers

Recent·Most cited

Data-independent acquisition (DIA) approach for comprehensive ubiquitinome profiling in targeted protein degradation

Gajanan J. Sathe, Sascha Röth, Géraldine Gelders, Abigail Brewer, Thomas Macartney, Nicola T. Wood, Louis De Muynck, Mark A. Nakasone, Toan K. Phung, Arjan Buist, Diederik Moechars, Gopal P. Sapkota

This study develops a DIA-based workflow for comprehensive ubiquitinome profiling in targeted protein degradation, identifying over 40,000 ubiquitylated peptides.

Scientific Reports · Sep 15, 2026Peer-reviewedCell Biology

In vivo validation of novel non-invasive PHP.eB AAVs as a potential therapeutic approach for alpha-Synucleinopathies

Maria Fouka, Iraklis Tsakogias, Elena Georgia Gialinaki, Athanasios Stavropoulos, Christiane Volbracht, Louis De Muynck, Diederik Moechars, Ronald Melki, George K. Tofaris, Leonidas Stefanis, Maria Xilouri

This study evaluates PHP.eB AAVs for reducing alpha-synuclein burden in a mouse model of alpha-synucleinopathies, showing reduced pathology and motor deficits.

Acta Neuropathologica Communications · Sep 29, 2025Peer-reviewedNeuroscience

Targeted degradation of α-synuclein prevents PFF-induced aggregation

Bill Carton, Géraldine Gelders, Gajanan J. Sathe, Nur Mehpare Kocatürk, Sascha Röth, Thomas Macartney, Joke Van Elsen, Louis De Muynck, Arjan Buist, Diederik Moechars, Gopal P. Sapkota

This study demonstrates targeted degradation of α-synuclein using a nanobody-guided system, preventing PFF-induced aggregation in neurons.

bioRxiv · Apr 15, 2025 · PreprintNeuroscience