Author

Maria I. Fonseca

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrea J. TenneriD· 2 shared Ángela Gómez-ArboledasiD· 2 shared Nicole D. SchartziD· 2 shared Purnika SelvaniD· 2 shared Shu‐Hui ChuiD· 2 shared Ali MortazaviiD· 1 shared Enikö A. KramáriD· 1 shared Gabriela Balderrama-GutierreziD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Andrea J. TennerORCID

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2 papers

Recent·Most cited

C5aR1 signaling promotes region and age dependent synaptic pruning in models of Alzheimers Disease

Ángela Gómez-Arboledas, Maria I. Fonseca, Enikö A. Kramár, Shu‐Hui Chu, Nicole D. Schartz, Purnika Selvan, Marcelo A. Wood, Andrea J. Tenner

This study shows that inhibiting C5aR1 reduces excessive synaptic pruning and synaptic loss in AD mouse models, improving LTP in an age and region-dependent manner.

Alzheimer s & Dementia · Jan 26, 2024Peer-reviewedNeuroscience

Modulation of C5a-C5aR1 signaling alters the dynamics of AD progression

Klébea Carvalho, Nicole D. Schartz, Gabriela Balderrama-Gutierrez, Heidi Yahan Liang, Shu‐Hui Chu, Purnika Selvan, Ángela Gómez-Arboledas, Tiffany J. Petrisko, Maria I. Fonseca, Ali Mortazavi, Andrea J. Tenner

This study shows that modulating C5a-C5aR1 signaling in Alzheimer's disease models affects cognitive decline and gene expression related to inflammation and astrocyte activation.

Journal of Neuroinflammation · Jul 11, 2022Peer-reviewedNeuroscience