Shu‐Hui Chu

This study shows that deleting microglial C1q in young adult Alzheimer's mice reduces synaptic engulfment and preserves cognition without affecting amyloid levels.

This study shows that inhibiting C5aR1 reduces excessive synaptic pruning and synaptic loss in AD mouse models, improving LTP in an age and region-dependent manner.

Pharmacologic inhibition of C5aR1 suppresses disease-enhancing processes and promotes disease mitigating pathways in an aggressive model of Alzheimer's disease.

The paper shows that C5aR1 antagonism reduces amyloid load and dystrophic neurites in a mouse model of Alzheimer's disease, shifting microglial polarization toward a neuroprotective phenotype.

This study shows that modulating C5a-C5aR1 signaling in Alzheimer's disease models affects cognitive decline and gene expression related to inflammation and astrocyte activation.

TALON annotates and counts full-length reads from PacBio or Nanopore in one framework; in mouse brain, 422 genes showed more novel-isoform reads than annotated ones.