Andrea J. Tenner

C5aR1 inhibition alleviates cranial radiation-induced cognitive decline

This study shows that inhibiting C5aR1 reduces radiation-induced cognitive decline in mice, improving memory and reducing neuroinflammation without affecting tumor treatment.

Young adult microglial deletion of C1q reduces engulfment of synapses and prevents cognitive impairment in an aggressive Alzheimer's disease mouse model

This study shows that deleting microglial C1q in young adult Alzheimer's mice reduces synaptic engulfment and preserves cognition without affecting amyloid levels.

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology

The paper investigates how the APOE Christchurch variant affects microglial responses to amyloid and tau pathology in mouse models, finding it enhances plaque-related responses but suppresses tau-related inflammation.

C5aR1 signaling promotes region and age dependent synaptic pruning in models of Alzheimers Disease

This study shows that inhibiting C5aR1 reduces excessive synaptic pruning and synaptic loss in AD mouse models, improving LTP in an age and region-dependent manner.

C5aR1 antagonism suppresses inflammatory glial gene expression and alters cellular signaling in an aggressive Alzheimer's model

Pharmacologic inhibition of C5aR1 suppresses disease-enhancing processes and promotes disease mitigating pathways in an aggressive model of Alzheimer's disease.

A Trem2*R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques

C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimers disease

The paper shows that C5aR1 antagonism reduces amyloid load and dystrophic neurites in a mouse model of Alzheimer's disease, shifting microglial polarization toward a neuroprotective phenotype.

Modulation of C5a-C5aR1 signaling alters the dynamics of AD progression

This study shows that modulating C5a-C5aR1 signaling in Alzheimer's disease models affects cognitive decline and gene expression related to inflammation and astrocyte activation.

Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimer's Disease

This paper characterizes the 3xTg-AD mouse model of Alzheimer's Disease across its lifespan and compares it with the 5xFAD model to assess pathology and model drift.

Systematic Phenotyping and Characterization of the 5xFAD mouse model of Alzheimer's Disease

The paper performs a comprehensive phenotypic analysis of the 5xFAD mouse model across its lifespan, identifying novel age-related pathological features.

Single-cell and nucleus RNA-seq in a mouse model of AD reveal activation of distinct glial subpopulations in the presence of plaques and tangles

The paper uses single-cell and nucleus RNA-seq to analyze glial subpopulations in AD mouse models, finding differences in astrocyte activation and microglia subtypes between 3xTg-AD and 5xFAD models.

Complement factor C1q mediates chronic neuron loss and inflammation post-brain injury

This study shows that C1q mediates chronic neuron loss and inflammation after brain injury by targeting the corticothalamic circuit in mice.

A technology-agnostic long-read analysis pipeline for transcriptome discovery and quantification

TALON annotates and counts full-length reads from PacBio or Nanopore in one framework; in mouse brain, 422 genes showed more novel-isoform reads than annotated ones.