The mitotic stopwatch limits the proliferation of whole genome doubled cells
Lindsey A Allan, Reece Foy, Maria Keli, Adrian Thomas Saurin
The paper shows that the mitotic stopwatch, a p53/53BP1/USP28-dependent pathway, arrests tetraploid cells after extended mitotic delays, independent of centrosome amplification, and is influenced by p21 levels and cell size.
bioRxiv · Sep 18, 2025 · PreprintCell Biology