Adrian Thomas Saurin

This paper develops a mathematical model to explain how paclitaxel selectively kills tumour cells by exploiting differences in perfusion and drug retention between tumour and healthy tissues.

The paper shows that the mitotic stopwatch, a p53/53BP1/USP28-dependent pathway, arrests tetraploid cells after extended mitotic delays, independent of centrosome amplification, and is influenced by p21 levels and cell size.

The paper shows that CDK4/6 inhibitor-treated cells that evade senescence experience mitotic errors and aneuploidy due to cell enlargement, which can be rescued by restoring cohesion.

This study identifies PHD1-dependent hydroxylation of RepoMan at P604, showing it regulates mitotic progression by modulating PP2A interaction and H3T3 phosphorylation.

The paper develops a chemical-genetic system to inhibit PP2A-B56 phosphatase by blocking SLiM-binding pockets, revealing its role in kinetochore-microtubule attachments.

Elraglusib causes cytotoxicity by directly destabilizing microtubules, leading to mitotic arrest, DNA damage, and apoptosis, independent of GSK3 inhibition.