A p53-ΔNp73 signaling axis drives selective motor neuron degeneration in spinal muscular atrophy
Maria Jose Carlini, Xuemei Hu, Leonie Sowoidnich, Archana Yadav, Jorge García, Maria Savin, Charlotte J. Sumner, Vilas Menon, Christian M. Simon, Livio Pellizzoni
This study identifies a p53-ΔNp73 signaling axis that drives motor neuron degeneration in SMA, revealing a context-dependent switch in p53 family signaling that promotes neurodegeneration.
bioRxiv · Jun 25, 2026 · PreprintNeuroscience