Archana Yadav

Disrupted glial-mediated synaptic refinement in Fragile X syndrome

This study identifies impaired glial-mediated synaptic refinement in FXS model mice, showing enhanced astrocyte-microglia signaling and synaptic over-engulfment as key features.

A p53-ΔNp73 signaling axis drives selective motor neuron degeneration in spinal muscular atrophy

This study identifies a p53-ΔNp73 signaling axis that drives motor neuron degeneration in SMA, revealing a context-dependent switch in p53 family signaling that promotes neurodegeneration.

Electrophysiologically Targeted Biopsies Reveal the Transcriptional Landscape of Focal Epilepsy

This study uses electrophysiologically guided biopsies and single-nucleus RNA sequencing to identify transcriptional differences between seizure focus and ictal penumbra in focal epilepsy.

Regulation of lipid dysmetabolism and neuroinflammation progression linked with Alzheimer's disease through modulation of Dgat2

This study identifies Dgat2 as a key modulator linking amyloid pathology, lipid dysregulation, and neuroinflammation in Alzheimer's disease across Drosophila and mouse models.

Ontogeny of the spinal cord dorsal horn

This paper investigates how the dorsal horn of the spinal cord develops, showing that neurons are diversified by time and spatial-molecular gradients, leading to the formation of laminae.

Multi-laboratory Study Establishes Reproducible Methods for Plant-Microbiome Research in Fabricated Ecosystems

The paper establishes reproducible methods for plant-microbiome research using fabricated ecosystems across multiple laboratories.

A stable 15-member bacterial SynCom promotes Brachypodium growth under drought stress

The paper constructs a 15-member bacterial SynCom that enhances Brachypodium growth under drought stress by incorporating plant growth-promoting traits and osmoprotectant synthesis.

Cell type-specific associations with Alzheimer's Disease conserved across racial and ethnic groups

The paper identifies cell-type-specific and continuous gene programs associated with Alzheimer's Disease across multiple racial and ethnic groups using single-nucleus RNA-seq and ATAC-seq.

A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson's Disease

The paper identifies a specific subtype of dopaminergic neurons, Anxa1+, that are selectively lost in Parkinson's disease and contribute to early motor symptoms.

A Cellular Taxonomy of the Adult Human Spinal Cord

This paper presents a cellular taxonomy of the adult human spinal cord using single nucleus RNA-sequencing and spatial transcriptomics, identifying 29 glial and 35 neuronal clusters and highlighting motoneuron vulnerability to ALS.