Author

Maria Jose Carlini

Columbia UniversityORCID 0000-0002-0530-3399Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Livio PellizzoniiD· 4 shared Marina K TriplettiD· 2 shared Shubhi Yadav· 2 shared Adele D’AmicoiD· 1 shared Alessandro UsielloiD· 1 shared Amber HassaniD· 1 shared Archana YadaviD· 1 shared Charlotte J. SumneriD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersNeuroscience

Livio PellizzoniORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A p53-ΔNp73 signaling axis drives selective motor neuron degeneration in spinal muscular atrophy

Maria Jose Carlini, Xuemei Hu, Leonie Sowoidnich, Archana Yadav, Jorge García, Maria Savin, Charlotte J. Sumner, Vilas Menon, Christian M. Simon, Livio Pellizzoni

This study identifies a p53-ΔNp73 signaling axis that drives motor neuron degeneration in SMA, revealing a context-dependent switch in p53 family signaling that promotes neurodegeneration.

bioRxiv · Jun 25, 2026 · PreprintNeuroscience

A chemical screen identifies p38 MAPK inhibition as a candidate neuroprotective strategy for combinatorial SMA therapy

Maria Jose Carlini, Jorge Espinoza‐Derout, Meaghan Van Alstyne, Sarah Tisdale, Eileen Workman, Marina K Triplett, Ivan Tattoli, Shubhi Yadav, Christopher E. Henderson, Daniel Martin Watterson, Livio Pellizzoni

This study identifies p38 MAPK inhibition as a neuroprotective strategy that synergizes with SMN upregulation to improve motor function and survival in SMA mice.

bioRxiv · Mar 6, 2025 · PreprintNeuroscience

Dysregulated balance of D- and L-amino acids modulating glutamatergic neurotransmission in severe spinal muscular atrophy.

Amber Hassan, Raffaella di Vito, Tommaso Nuzzo, Matteo Vidali, Maria Jose Carlini, Shubhi Yadav, Hua Yang, Adele D’Amico, Xhesika Kolici, Valeria Valsecchi, Chiara Panicucci, Giuseppe Pignataro, Claudio Bruno, Enrico Bertini, Francesco Errico, , Alessandro Usiello

The paper investigates amino acid metabolism in spinal muscular atrophy, finding dysregulated D- and L-amino acid levels linked to glutamatergic dysfunction and showing therapeutic potential with D-serine.

Neurobiology of Disease · Feb 24, 2025Peer-reviewedNeuroscience

Neuromuscular denervation and deafferentation but not motor neuron death are disease features in the Smn 2B/- mouse model of SMA

Maria Jose Carlini, Marina K Triplett, Livio Pellizzoni

This study investigates SMA pathology in Smn2B/- mice, finding that neuromuscular denervation and deafferentation, not motor neuron death, are consistent features of the disease.

PLoS ONE · Aug 1, 2022Peer-reviewedNeuroscience