Local Confinement within Plasma Membrane Nanodomains Promotes Constitutive Activity of GPCRs
Xiaohan Zhou, Maria Shemeteva, François Simon, Louis-Philippe Picard, Aiyan Brown, Gurveen K. Dhillon, Malene L. Urbanus, Lucien E. Weiss, Robert Scott Prosser, Claudiu C. Gradinaru
The paper investigates how membrane nanodomains influence constitutive activity of GPCRs, finding that A2AR is confined in nanodomains with Gas, promoting basal signaling.
bioRxiv · Oct 22, 2026 · PreprintBiophysics