Author

Claudiu C. Gradinaru

University of TorontoORCID 0000-0002-1897-313XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Approach:simulation· 1

Frequent Co-Authors

Aiyan BrowniD· 2 shared François SimoniD· 1 shared Graeme MilliganiD· 1 shared Gurveen K. Dhillon· 1 shared Horacio Septien-Gonzalez· 1 shared Julie Deborah Forman-KayiD· 1 shared Louis-Philippe Picard· 1 shared Lucien E. WeissiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiophysics

Aiyan BrownORCID

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Author profile →

4 papers

Recent·Most cited

Local Confinement within Plasma Membrane Nanodomains Promotes Constitutive Activity of GPCRs

Xiaohan Zhou, Maria Shemeteva, François Simon, Louis-Philippe Picard, Aiyan Brown, Gurveen K. Dhillon, Malene L. Urbanus, Lucien E. Weiss, Robert Scott Prosser, Claudiu C. Gradinaru

The paper investigates how membrane nanodomains influence constitutive activity of GPCRs, finding that A2AR is confined in nanodomains with Gas, promoting basal signaling.

bioRxiv · Oct 22, 2026 · PreprintBiophysics

Conformational Ensembles of the Disordered 4E-BP2:eIF4E Complex Restrained by smFRET Experiments

Spencer Smyth, Zi Hao Liu, Thomas E. Tsangaris, Teresa L. Head-Gordon, Julie Deborah Forman-Kay, Claudiu C. Gradinaru

The paper generates conformational ensembles of the 4E-BP2:eIF4E complex using smFRET and NMR data, revealing dynamic structural changes and new contact regions.

Protein Science · Sep 15, 2026Peer-reviewedBiophysics

Parsing Contributions of Physical Phenomena to smFRET Statistical Inhomogeneity via Multiparameter Stochastic Simulations

Aiyan Brown, Claudiu C. Gradinaru

The paper develops a simulation framework to analyze how different physical processes affect smFRET data by isolating and varying their contributions.

The Journal of Chemical Physics · Apr 8, 2026Peer-reviewedBiophysics

Diffusion and Oligomerization States of the Muscarinic M1 Receptor in Live Cells - The Impact of Ligands and Membrane Disruptors

Xiaohan Zhou, Horacio Septien-Gonzalez, Sami Husaini, Richard John Ward, Graeme Milligan, Claudiu C. Gradinaru

This study uses single-molecule techniques to analyze the diffusion and oligomerization of M1R in live cells, showing ligands and membrane disruptors modulate these states.

The Journal of Physical Chemistry B · Apr 29, 2024Peer-reviewedBiophysics