Malene L. Urbanus

The paper investigates how membrane nanodomains influence constitutive activity of GPCRs, finding that A2AR is confined in nanodomains with Gas, promoting basal signaling.

The paper provides a global atlas of predicted functional domains in Legionella pneumophila effectors using 3D structure prediction, identifying novel domains and demonstrating their functional impact.

The paper uses a yeast two-hybrid screen to identify novel effector-effector interactions in L. pneumophila, doubling the known number of such interactions.

The paper presents a yeast-based method to identify informative missense mutations in bacterial effector proteins and validates it using three effectors from Legionella pneumophila.