Demyelination induces transcriptional reprogramming in proprioceptive and Aβ rapidly adapting low-threshold-mechanoreceptor neurons.
Benayahu Elbaz, Lite Yang, Braesen Lee Rader, Riki Kawaguchi, Maria Traka, Clifford J. Woolf, William R. Renthal, Brian Popko
The paper shows that Schwann cell loss causes demyelination and transcriptional reprogramming in specific sensory neurons, suggesting a non-cell autonomous response to axon-Schwann cell interaction loss.
bioRxiv · Nov 23, 2021 · PreprintNeuroscience