Riki Kawaguchi

A single-nucleus regulatory atlas links transposable elements to adult hippocampal neurogenesis

This study uses snATAC-seq and snRNA-seq to identify TE-derived regulatory elements involved in adult hippocampal neurogenesis in response to rhEPO stimulation.

A CK2α-G3BP1 signaling axis regulates local translation in developing neurons and is disrupted in OCNDS

This study identifies a CK2α-G3BP1 signaling axis critical for neuronal translation and development, showing its disruption causes OCNDS pathology.

Lesion-remote astrocytes govern microglia-mediated white matter repair

This study identifies lesion-remote astrocytes (LRAs) that drive microglia-mediated white matter repair after spinal cord injury through Ccn1-dependent mechanisms.

Dysregulation of transcription networks regulating oligodendrogenesis in age-related decline in CNS remyelination

The paper identifies age-related dysregulation of transcription networks in oligodendrocyte differentiation using single-nucleus RNA and ATAC sequencing in mice, with parallels in MS lesions.

Erythropoietin reshapes the adult hippocampal chromatin landscape to promote neurogenesis

This study shows EPO induces chromatin remodeling in adult mouse hippocampal neurons, revealing a transposon-mediated mechanism for neurogenesis.

Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration.

Transcriptional dynamics of the oligodendrocyte lineageand its regulation by the brain erythropoietin system

This study investigates how erythropoietin (EPO) and its receptor (EPOR) regulate oligodendrocyte lineage dynamics in the adult mouse hippocampus, showing EPO promotes differentiation and maturation, and suggests potential therapeutic applications for remyelination.

Lack of mRNA Methylation in Schwann Cells Results in Demyelination and Regenerative Failure

This study shows that lack of m6A methylation in Schwann cells causes demyelination and regenerative failure in mice.

A 4D transcriptomic map for the evolution of multiple sclerosis-like lesions in the marmoset brain

The paper identifies spatiotemporal diversity of primate brain cells during white matter inflammatory demyelination using a cross-modality approach to inform lesion detection and management in multiple sclerosis.

Brain-wide neuronal circuit connectome of human glioblastoma

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling

The paper identifies netrin1 as a suppressor of Bmp signaling in the dorsal spinal cord, altering interneuron patterning and Bmp activity through gain- and loss-of-function experiments in multiple models.

Aberrant gliogenesis and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids

Autism-like MEF2C+/- patient hiPSC models show miRNA-mediated overproduction of astrocytes and hyperactivity of neurons.

Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity

The paper investigates acute rapamycin treatment in a maternal inflammation mouse model of autism, showing rapid rescue of behavioral and functional dysfunctions linked to mTOR pathway activation.

Border-forming wound repair astrocytes

The paper identifies the cellular origins and functional changes of astrocytes forming protective borders around CNS injuries, showing their role in neuroprotection.

Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex

The paper identifies 46,802 enhancers and 164 psychiatric disorder variants with regulatory effects in the developing cortex and organoids using massively parallel reporter assays and deep learning.

Single-cell genomics and regulatory networks for 388 human brains

The paper processes single-nuclei multi-omics data from 388 human brains to identify regulatory elements and build cell-type networks, revealing changes in aging and neuropsychiatric disorders.

Molecular cascades and cell-type specific signatures in ASD revealed by single cell genomics

The paper uses single nuclear RNAseq and epigenetic profiling to identify molecular changes and cell-type specific signatures in ASD, linking them to genetic risk factors.

NEK1 modulates neurite outgrowth in motor neurons through coordinating retromer formation

This study identifies NEK1's role in motor neuron neurite outgrowth by coordinating retromer formation through interactions with SMC3.

Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus

This study shows that erythropoietin (EPO) reduces inhibitory potential in hippocampal interneurons, enhancing pyramidal neuron excitability and potentially improving neuropsychiatric symptoms.

Intercellular Signaling Pathways as Therapeutic Targets for Vascular Dementia Repair

This study identifies intercellular signaling pathways involved in vascular dementia repair and demonstrates therapeutic potential through drug intervention.

Macrophages protect against sensory axon degeneration in diabetic neuropathy

This study shows that macrophages protect against sensory axon degeneration in diabetic neuropathy by delaying axonal loss through CCR2 signaling.

Single-nucleus analysis characterizes non-enhancing region of recurrent high-grade glioma

The paper uses single-nucleus RNA-sequencing to compare non-enhancing and contrast-enhancing regions of high-grade gliomas, finding distinct cellular states and microenvironment features in NE regions.

A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences.

The paper develops a toolbox of astrocyte-specific AAV vectors using miRNA targeting sequences to reduce off-target expression in neurons and endothelial cells.

Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cellgenomics

The paper uses single-cell genomics to identify shared and disease-specific cell states and gene regulatory networks in three dementias, revealing distinct neuroimmune mechanisms and potential therapeutic targets.

A comparative analysis of microglial inducible Cre lines

This study evaluates four microglial inducible Cre lines, showing differences in recombination efficiency and spontaneous recombination, and provides best practices for measuring these in microglia.

BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice

This study shows that TREM2-R47H reduces amyloid plaques but fails to improve cognitive deficits or microglial reactivity in 5xFAD mice.

PTBP1 Regulates Injury Responses and Sensory Pathways in Adult Peripheral Neurons

This study shows PTBP1 is expressed in adult sensory and motor neurons, with increased axonal levels after injury, affecting axon outgrowth and sensation.

Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer's disease

This study shows that ageing-related myelin dysfunction drives amyloid-beta deposition in Alzheimer's disease mouse models, suggesting myelin integrity as an upstream risk factor.

Downregulation of the silent potassium channel Kv8.1 increases ALS motor neuron vulnerability

The paper shows that reduced Kv8.1 expression in ALS motor neurons with SOD1(A4V) and C9orf72 mutations increases vulnerability to cell death by affecting metabolism and transport pathways.

Transcriptional networks predating cognition-associated pyramidal lineages are restructured by erythropoietin

This study uses single-nucleus RNA sequencing to show that erythropoietin treatment restructures transcriptional networks in hippocampal pyramidal neurons, increasing their numbers and altering gene expression related to neurodifferentiation and cognition.