Lite Yang

The paper identifies cis-regulatory elements for targeted gene delivery to nociceptors using multi-omic profiling and develops a sequence-based model to design synthetic enhancers.

This paper creates a multi-omic atlas of human autonomic and sensory ganglia, identifying cell-type-specific features and disease associations in peripheral neuropathies.

The paper identifies a functional dichotomy in the ventrolateral periaqueductal gray, showing that micro opioid receptor neurons encode nociceptive states while enkephalin-releasing neurons drive pain relief in various contexts.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

This study creates a single-nucleus multi-omic atlas of human dorsal root ganglia, identifying novel regulatory mechanisms and therapeutic targets for pain.

The paper identifies Trpc4 interneurons in the spinal cord that gate bladder sensory input and regulate micturition reflexes, revealing their role in bladder-sphincter coordination and visceral pain.

The paper identifies CeA neuronal ensembles that modulate visceral pain and its affective behaviors through optogenetic manipulation and single-nucleus RNA sequencing.

The paper introduces Projection-TAGs, a tool for multiplex projection tracing and multi-modal profiling of projection neurons in mice.

This study links electrical properties to transcriptional identities in human sensory neurons, identifying associations between pain history and specific electrophysiological subtypes.

The paper defines the transcriptional taxonomy of ventral pallidum cell types across mice, macaques, and baboons using snRNA-seq and in situ hybridization, finding transcriptional conservation and unique subclusters in primates.

The paper builds harmonized cross-species cell atlases of DRG and TG, identifies 29 cell types across 6 species, and shows transcriptomic similarities and differences in sensory neurons.

The paper characterizes the transcriptional profile of Satellite Glial Cells (SGC) in mouse, rat, and human at the single-cell level, finding conserved key features across species.

The paper shows that Schwann cell loss causes demyelination and transcriptional reprogramming in specific sensory neurons, suggesting a non-cell autonomous response to axon-Schwann cell interaction loss.

The paper shows that peripheral sensory neurons undergo consistent transcriptional changes after axonal injury, which promote regeneration but also suppress cell identity, with Atf3 playing a key role.