Brian Popko

This study identifies oligodendrocyte stress response as a driver of vascular dementia by showing its role in myelin damage and cognitive impairments in mice and humans.

AA147 reduces oligodendrocyte loss and demyelination in a mouse model of MS by activating ATF6 and NRF2 pathways, improving clinical symptoms and microglia activation.

This study investigates how combining Sephin1 and BZA accelerates remyelination under inflammation by modulating the integrated stress response in oligodendrocytes.

The paper shows that myelin acts as an energy reserve in the brain under glucose deprivation, supporting oligodendrocytes and axons through fatty acid oxidation.

The paper shows that Schwann cell loss causes demyelination and transcriptional reprogramming in specific sensory neurons, suggesting a non-cell autonomous response to axon-Schwann cell interaction loss.

This study shows that enhancing the integrated stress response (ISR) improves remyelination in inflammatory CNS lesions in mice.

This study evaluates the PET tracer [18F]3F4AP in rhesus macaques for detecting demyelination, showing higher sensitivity than existing tracers and MRI methods.

This study identifies synapse loss and microglial synaptic engulfment in MS models and demonstrates that targeted complement inhibition prevents synapse loss and visual dysfunction.