Supramolecular Site-Specific Antibody Drug Conjugates Outperform Cysteine-Conjugated Analogs in Pancreatic Peritoneal Carcinomatosis
Christopher M. Gromisch, Alina Ringaci, Aladin Hamoud, Samantha Berry, Mariana Gromisch, W. Mark Saltzman, Mark W. Grinstaff
This paper develops a supramolecular ADC conjugation method that improves drug loading and efficacy in pancreatic cancer compared to cysteine-conjugated analogs.
bioRxiv · Aug 6, 2026 · PreprintBioengineering