W. Mark Saltzman

This paper develops a supramolecular ADC conjugation method that improves drug loading and efficacy in pancreatic cancer compared to cysteine-conjugated analogs.

The study shows that endothelial cell MHC molecules are critical for rejecting 3D-printed human skin grafts in an immunocompetent humanized mouse model.

This study observes a mosaic pattern of aerosol distribution in alveoli across species and ages, revealing functional heterogeneity in lung deposition and its implications for disease and therapy.

This study demonstrates systemic in utero gene editing using PNAs in nanoparticles to correct CFTR mutations in multiple organs of CF mice, showing sustained CFTR activity without off-target effects.

This paper demonstrates that hydroxymethyl-γ PNA oligomers enhance gene modification in mouse bone marrow cells compared to diethylene glycol-γ PNA.