SERINC5 co-expressed with HIV-1 Env or present in a target membrane destabilizes small fusion pores leading to their collapse
Ruben M. Markosyan, Mariana Marin, Gregory B. Melikyan
This paper shows SERINC5 inhibits HIV-1 fusion by destabilizing small fusion pores in target or effector cells, independent of its presence in virions.
mBio · Nov 17, 2025Peer-reviewedMicrobiology