Author

Ruben M. Markosyan

Rush University Medical CenterORCID 0000-0002-1412-8641Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

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Gregory B. MelikyaniD· 1 shared Mariana Marin· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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1 shared paperMicrobiology

Gregory B. MelikyanORCID

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1 paper

Recent·Most cited

MicrobiologymBioPeer-reviewedNov 17, 2025

SERINC5 co-expressed with HIV-1 Env or present in a target membrane destabilizes small fusion pores leading to their collapse

Ruben M. Markosyan, Mariana Marin, Gregory B. Melikyan

This paper shows SERINC5 inhibits HIV-1 fusion by destabilizing small fusion pores in target or effector cells, independent of its presence in virions.

DOI 10.1128/mbio.02793-25

humanproteomics

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