Nuclear Speckle Dynamics are Controlled by Polyphosphate Inhibition of CLK Proteins
Blanca Lázaro, Francisco J. Tadeo, Andrea Rodríguez, Lucía Ayuso-Molina, Joan Marc Martínez‐Láinez, Eva Quandt, Maribel Bernard, Filipy Borghi, Adolfo Saiardi, Jonàs Juan‐Mateu, Javier Jiménez, Josep Clotet, Samuel Bru
This study identifies polyphosphate as a regulator of nuclear speckle dynamics by inhibiting CLK3 kinase, affecting splicing factor organization and RNA splicing.
Nucleic Acids Research · Mar 25, 2026Peer-reviewedCell Biology