Adolfo Saiardi

The paper shows that the PPIP5K enzyme Asp1 produces opposite effects on fungal morphology and actin organization in different species, depending on the host cellular environment.

This paper develops [13C6]scyllo-inositol as an isotopic tracer to study its metabolism and shows its incorporation into phosphatidylinositols in mammalian cells.

This study identifies polyphosphate as a regulator of nuclear speckle dynamics by inhibiting CLK3 kinase, affecting splicing factor organization and RNA splicing.

The paper shows that phytic acid activates the HDAC3 epigenetic axis to maintain intestinal barrier function, with therapeutic potential in inflammatory bowel disease.

This study shows that inositol hexakisphosphate (IP6) is an essential cofactor for ADAR1 activity, with its depletion reducing RNA editing and supplementation restoring it.

The paper uses 18O-water labeling to study phosphate group dynamics in inositol phosphates across species, revealing distinct pools with different cycling behaviors.

The paper introduces a FRET-based assay to detect endopolyphosphatase activity in yeast, revealing a novel Mn2+-dependent enzyme in a quadruple mutant.

The paper profiles inositol pyrophosphates in mammalian organs, identifies IP6K2 as a key enzyme for IP7 metabolism in the enteric nervous system, and shows its role in neuronal development and function.

The paper shows that 3UTR cleavage occurs in sympathetic neuron axons, mediated by Ago2 and HuD, and regulates local protein synthesis and generates new 3UTR RNA fragments.

This study identifies MINPP1 mutations as a cause of Pontocerebellar Hypoplasia, showing that MINPP1 deficiency leads to IP6 accumulation and cation chelation, disrupting brain development.