Samuel Bru

This study identifies polyphosphate as a regulator of nuclear speckle dynamics by inhibiting CLK3 kinase, affecting splicing factor organization and RNA splicing.

The paper investigates how acidocalcisome-like vacuoles regulate cytosolic phosphate levels through polyphosphate synthesis and feedback mechanisms.

The paper introduces a FRET-based assay to detect endopolyphosphatase activity in yeast, revealing a novel Mn2+-dependent enzyme in a quadruple mutant.