Human stem cell derived neurons and astrocytes to detect novel auto-reactive IgG signature in immune-mediated neurological diseases
Amandine Mathias, Sylvain Perriot, Samuel Jones, Mathieu Canales, Raphaël Bernard‐Valnet, Marie Gimenez, Nathan Torcida, Larise Oberholster, Andreas Felix Hottinger, Αναστασία Ζεκερίδου, Marie Théaudin, Caroline Pot, Renaud Du Pasquier
This study develops a cell-based assay using human iPSC-derived neurons and astrocytes to detect novel neural-reactive antibodies in patients with immune-mediated neurological diseases, finding higher reactivity in inflammatory disease groups.
bioRxiv · Feb 26, 2024 · PreprintNeuroscience