Sylvain Perriot

Human stem cell derived neurons and astrocytes to detect novel auto-reactive IgG signature in immune-mediated neurological diseases

This study develops a cell-based assay using human iPSC-derived neurons and astrocytes to detect novel neural-reactive antibodies in patients with immune-mediated neurological diseases, finding higher reactivity in inflammatory disease groups.

Comprehensive proteomic analysis of JC polyomavirus-infected human astrocytes and their excreted vesicles

This study shows JCPyV infects astrocytes, dysregulates cell biology, and affects excreted vesicles, providing insights into PML pathogenesis.

Accumulation of Tau in Extracellular Vesicles Disturbs the Astrocytic Mitochondrial System

This study shows that tau-containing extracellular vesicles from neurons transfer tau to astrocytes, disrupting their mitochondrial function, with 3R tau being more damaging than 4R tau.