Author

Marie Leverve

Centre National de la Recherche Scientifique

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Genetics· 1

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Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Adriana Alves· 1 shared Adrienne Margaret FlanaganiD· 1 shared Bart VanhaesebroeckiD· 1 shared Cheryl L. ScudamoreiD· 1 shared Djenat Belarbi· 1 shared Elizabeth FoxalliD· 1 shared Fiona Black· 1 shared Gala Anastasia Electra Classen· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperGenetics

Adriana Alves

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1 paper

Recent·Most cited

A mouse model of PTEN Hamartoma Tumour Syndrome reveals that loss of the nuclear function of PTEN drives macrocephaly, lymphoid overgrowth, and late-onset cancer

Priyanka Tibarewal, Victoria Rathbone, Sarah E. Conduit, Gala Anastasia Electra Classen, Fiona Black, Mohammad Amin Danesh, Georgia Constantinou, Zeinab Asgarian, Koujiro Tohyama, Nisha Kriplani, Virginia Alvarez Garcia, Elizabeth Foxall, Djenat Belarbi, Marie Leverve, Wayne P Pearce, , Bart Vanhaesebroeck

This study shows that a specific PTEN mutation causes macrocephaly, lymphoid overgrowth, and late-onset cancer in mice by impairing nuclear PTEN functions, while maintaining normal PI3K/AKT signaling.

Disease Models & Mechanisms · Nov 11, 2025Peer-reviewedGenetics