Author

Nisha Kriplani

Heriot-Watt University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Bart VanhaesebroeckiD· 2 shared Mahreen AdiliD· 2 shared Nicholas R. LeslieiD· 2 shared Priyanka TibarewaliD· 2 shared Zofia VaryovaiD· 2 shared Adriana Alves· 1 shared Adrienne Margaret FlanaganiD· 1 shared C. Peter Downes· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Bart VanhaesebroeckORCID

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2 papers

Recent·Most cited

Evidence that the protein phosphatase activity of PTEN contributes to embryonic development and tumour suppression in mice

Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen M. Wise, Nadège Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len Stephens, Kate G. Storey, Doreen Ann Cantrell, , Nicholas R. Leslie

This study shows that PTEN's protein phosphatase activity is essential for embryonic development and tumor suppression in mice, as demonstrated by mutant mice with impaired protein phosphatase activity.

bioRxiv · Mar 17, 2026 · PreprintCancer Biology

A mouse model of PTEN Hamartoma Tumour Syndrome reveals that loss of the nuclear function of PTEN drives macrocephaly, lymphoid overgrowth, and late-onset cancer

Priyanka Tibarewal, Victoria Rathbone, Sarah E. Conduit, Gala Anastasia Electra Classen, Fiona Black, Mohammad Amin Danesh, Georgia Constantinou, Zeinab Asgarian, Koujiro Tohyama, Nisha Kriplani, Virginia Alvarez Garcia, Elizabeth Foxall, Djenat Belarbi, Marie Leverve, Wayne P Pearce, , Bart Vanhaesebroeck

This study shows that a specific PTEN mutation causes macrocephaly, lymphoid overgrowth, and late-onset cancer in mice by impairing nuclear PTEN functions, while maintaining normal PI3K/AKT signaling.

Disease Models & Mechanisms · Nov 11, 2025Peer-reviewedGenetics