Author

Koujiro Tohyama

Iwate Medical UniversityORCID 0000-0002-6919-2704Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Huiliang LiiD· 2 shared Katsutoshi Ogasawara· 2 shared Matthew SwireiD· 2 shared Stuart G. NayariD· 2 shared William David RichardsoniD· 2 shared Yi JiangiD· 2 shared Adam Halko· 1 shared Adriana Alves· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Huiliang LiORCID

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3 papers

Recent·Most cited

Intact learning and memory in mice incapable of de novo myelination

Matthew Swire, Stuart G. Nayar, Yi Jiang, Adam Halko, Marcus Lloyd, Katsutoshi Ogasawara, Koujiro Tohyama, Thomas Philips, Jeffrey D. Rothstein, Huiliang Li, William David Richardson

This study shows that motor and fear learning in mice do not require newly formed myelin sheaths or rapid saltatory conduction, as Mbp-cKO mice with impaired myelination still learned and remembered normally.

bioRxiv · Jun 16, 2026 · PreprintNeuroscience

A mouse model of PTEN Hamartoma Tumour Syndrome reveals that loss of the nuclear function of PTEN drives macrocephaly, lymphoid overgrowth, and late-onset cancer

Priyanka Tibarewal, Victoria Rathbone, Sarah E. Conduit, Gala Anastasia Electra Classen, Fiona Black, Mohammad Amin Danesh, Georgia Constantinou, Zeinab Asgarian, Koujiro Tohyama, Nisha Kriplani, Virginia Alvarez Garcia, Elizabeth Foxall, Djenat Belarbi, Marie Leverve, Wayne P Pearce, , Bart Vanhaesebroeck

This study shows that a specific PTEN mutation causes macrocephaly, lymphoid overgrowth, and late-onset cancer in mice by impairing nuclear PTEN functions, while maintaining normal PI3K/AKT signaling.

Disease Models & Mechanisms · Nov 11, 2025Peer-reviewedGenetics

Oligodendrocyte dynamics dictate individual performance outcomes of working memory training in mice

Takahiro Shimizu, Stuart G. Nayar, Matthew Swire, Yi Jiang, Matthew Grist, Malte S. Kaller, Cassandra Sampaio‐Baptista, David M. Bannerman, Heidi Johansen‐Berg, Katsutoshi Ogasawara, Koujiro Tohyama, Huiliang Li, William David Richardson

The paper shows that oligodendrocyte production is crucial for improving working memory performance in mice during maze training.

bioRxiv · Jan 17, 2023 · PreprintNeuroscience