Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF)
Andrew Gibb, Kyle Brian LaPenna, Ryan B. Gaspar, Nadina R. Latchman, Yin Fei Tan, Carmen Choya-Foces, Jake E. Doiron, Zhen Li, Huijing Xia, Michael P. Lazaropoulos, Mariell Conwell, Thomas E. Sharp, Traci T. Goodchild, David J. Lefer, John W. Elrod
The paper uses systems biology to identify mitochondrial dysfunction and metabolic disruptions as key factors in HFpEF using a rat model.
bioRxiv · Oct 25, 2024 · PreprintMolecular Biology