Author

Thomas E. Sharp

University of South FloridaORCID 0000-0001-8706-9825Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:rat· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

David J. LeferiD· 3 shared Huijing XiaiD· 3 shared Jake E. DoironiD· 3 shared Kyle Brian LaPennaiD· 3 shared Traci T. GoodchildiD· 3 shared Zhen LiiD· 3 shared Alexia A. ZagourasiD· 2 shared Heather D. QuiriarteiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPhysiology

David J. LeferORCID

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Author profile →

3 papers

Recent·Most cited

PhysiologyCirculation ResearchPeer-reviewedSep 17, 2025

Dysregulation of Nitrosylation Dynamics Promotes Nitrosative Stress and Contributes to Cardiometabolic Heart Failure with Preserved Ejection Fraction

Zhen Li, Kyle Brian LaPenna, Natalie Gehred…·David J. Lefer

This study identifies dysregulated nitrosylation dynamics in HFpEF patients and ZSF1 obese rats, showing elevated nitrosative stress markers and impaired trans- and de-nitrosylase activity.

16 citationstop 1%

humanrat

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Pharmacology & ToxicologyJACC Basic to Translational SciencePeer-reviewedAug 6, 2025

Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit with GLP-1/Glucagon Agonism

Jake E. Doiron, Mahmoud H. Elbatreek, Huijing Xia…·David J. Lefer

This study shows H2S deficiency in HFpEF patients and models, and that H2S supplementation or combination with GLP-1/glucagon agonists improves HFpEF outcomes.

9 citations

humanmouse

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Molecular BiologybioRxivPreprintOct 25, 2024

Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF)

Andrew Gibb, Kyle Brian LaPenna, Ryan B. Gaspar…·John W. Elrod

The paper uses systems biology to identify mitochondrial dysfunction and metabolic disruptions as key factors in HFpEF using a rat model.

3 citations

ratbulk RNA-seq

𝕏 PostBluesky