Author

Jake E. Doiron

Louisiana State University Health Sciences Center New OrleansORCID 0000-0002-4584-4819Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2 Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:rat· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

David J. LeferiD· 4 shared Traci T. GoodchildiD· 4 shared Zhen LiiD· 4 shared Huijing XiaiD· 3 shared Kyle Brian LaPennaiD· 3 shared Sanjiv Jayendra ShahiD· 3 shared Thomas E. SharpiD· 3 shared Timothy Daniel AllertoniD· 3 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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4 shared papersPhysiology

David J. LeferORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multiomics Integration Reveals a Metabolic Myopathy in Cardiometabolic HFpEF

Timothy Daniel Allerton, Daniel A. Arabie, Kade Malone, Abhishek Pandit, Mahmoud H. Elbatreek, Zhen Li, Robert C. Noland, Jake E. Doiron, Mike Kinter, Brooke L. Loveland, Pravalika Javvadi, Kirti Agrawal, Manas Ranjan Gartia, Praveen Guttula, Traci T. Goodchild, , David J. Lefer

This study identifies a metabolic myopathy in HFpEF through multiomics analysis of skeletal muscle, revealing mitochondrial dysfunction and altered amino acid metabolism.

bioRxiv · Dec 18, 2025 · PreprintPhysiology

Dysregulation of Nitrosylation Dynamics Promotes Nitrosative Stress and Contributes to Cardiometabolic Heart Failure with Preserved Ejection Fraction

Zhen Li, Kyle Brian LaPenna, Natalie Gehred, Xiaoman Yu, W.H. Wilson Tang, Jake E. Doiron, Huijing Xia, Jingshu Chen, Ian H. Driver, Frank B. Sachse, Naoto Muraoka, Antonia Katsouda, Paraskevas Zampas, Amelia G. Haydel, Heather D. Quiriarte, , David J. Lefer

This study identifies dysregulated nitrosylation dynamics in HFpEF patients and ZSF1 obese rats, showing elevated nitrosative stress markers and impaired trans- and de-nitrosylase activity.

Circulation Research · Sep 17, 2025Peer-reviewedPhysiology

Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit with GLP-1/Glucagon Agonism

Jake E. Doiron, Mahmoud H. Elbatreek, Huijing Xia, Xiaoman Yu, Natalie Gehred, Tatiana Gromova, Jingshu Chen, Ian H. Driver, Naoto Muraoka, Martin Borch Jensen, Smitha Shambhu, W.H. Wilson Tang, Kyle Brian LaPenna, Thomas E. Sharp, Traci T. Goodchild, , David J. Lefer

This study shows H2S deficiency in HFpEF patients and models, and that H2S supplementation or combination with GLP-1/glucagon agonists improves HFpEF outcomes.

JACC Basic to Translational Science · Aug 6, 2025Peer-reviewedPharmacology & Toxicology

Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF)

Andrew Gibb, Kyle Brian LaPenna, Ryan B. Gaspar, Nadina R. Latchman, Yin Fei Tan, Carmen Choya-Foces, Jake E. Doiron, Zhen Li, Huijing Xia, Michael P. Lazaropoulos, Mariell Conwell, Thomas E. Sharp, Traci T. Goodchild, David J. Lefer, John W. Elrod

The paper uses systems biology to identify mitochondrial dysfunction and metabolic disruptions as key factors in HFpEF using a rat model.

bioRxiv · Oct 25, 2024 · PreprintMolecular Biology