NIPBL and STAG1 enable loop extrusion by providing differential DNA-cohesin affinity
Raman van Wee, Roi Asor, Yiwen Li, David N. Drechsel, Mariia Popova, Gabriele Litos, Iain F. Davidson, Jan‐Michael Peters, Philipp Kukura
This study identifies NIPBL and STAG1's roles in cohesin-mediated DNA loop extrusion by analyzing their differential DNA-cohesin interactions and ATP-dependent regulation.
Proceedings of the National Academy of Sciences · Aug 5, 2025Peer-reviewedBiophysics