Collagen Prolyl Hydroxylases Regulate HIF-α Levels Independently of pVHL in ccRCC
Yangsook Song Green, Karen Acuña-Pilarte, Marin Jones, Lily Marie-Therese Halberg, Thai H. Ho, Mei Yee Koh
This study shows collagen PHDs P4HA1 and P4HA2 regulate HIF-1/2 levels in ccRCC independently of pVHL, through collagen production, suggesting P4HA1/2 inhibition as a therapeutic strategy.
bioRxiv · Sep 14, 2025 · PreprintCancer Biology