Cancer BiologybioRxivPreprint
Collagen Prolyl Hydroxylases Regulate HIF-α Levels Independently of pVHL in ccRCC
Yangsook Song Green, Karen Acuña-Pilarte, Marin Jones…·Mei Yee Koh
This study shows collagen PHDs P4HA1 and P4HA2 regulate HIF-1/2 levels in ccRCC independently of pVHL, through collagen production, suggesting P4HA1/2 inhibition as a therapeutic strategy.
DOI 10.1101/2025.09.14.676157