Synthetic STARR-seq reveals how DNA shape and sequence modulate transcriptional output and noise.
Stefanie Schöne, Melissa Bothe, Edda Einfeldt, Marina Borschiwer, Philipp Benner, Martin Vingron, Morgane Thomas‐Chollier, Sebastiaan H. Meijsing
This study develops synSTARR-seq to analyze how DNA sequence and shape affect transcriptional activity and noise using synthetic GR binding sites.
PLoS Genetics · Nov 14, 2018Peer-reviewedSystems Biology