Sebastiaan H. Meijsing

Assessment of glucocorticoid-induced enhancer activity of eSNP regions using STARR-seq reveals novel molecular mechanisms in psychiatric disorders

Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq

The paper quantifies enhancer activity dynamics in mESCs during differentiation using FAIRE-STARR-seq, identifying features that predict enhancer activity and reveal regulatory insights.

Glucocorticoid receptor activation induces gene-specific transcriptional memory and universally reversible changes in chromatin accessibility

The paper shows that glucocorticoid receptor activation leads to reversible chromatin changes and gene-specific transcriptional memory in human airway epithelial cells.

Androgen and glucocorticoid receptor direct distinct transcriptional programs by receptor-specific and shared DNA binding sites

This study identifies mechanisms by which androgen and glucocorticoid receptors achieve functional diversification through distinct DNA binding and downstream regulatory events.

CRUP: A comprehensive framework to predict condition-specific regulatory units

CRUP predicts condition-specific regulatory units by analyzing histone modification ChIP-seq data and linking enhancers to target genes in rheumatoid arthritis.

Synthetic STARR-seq reveals how DNA shape and sequence modulate transcriptional output and noise.

This study develops synSTARR-seq to analyze how DNA sequence and shape affect transcriptional activity and noise using synthetic GR binding sites.